Table 7.
Association Between SNPs and Risk of Adenocarcinoma, Squamous Cell Carcinoma and Small Cell Lung Cancer
| SNP | Model | Genotype | Adenocarcinoma | Squamous Cell Carcinoma | Small Cell Lung Cancer | |||
|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | |||
| rs13098637 | Dominant | T/T | 1 | 0.019* | 1 | 0.180 | 1 | 0.009* |
| T/C-C/C | 1.44 (1.06–1.95) | 1.28 (0.90–1.83) | 1.78 (1.16–2.71) | |||||
| Recessive | T/T-T/C | 1 | 0.028* | 1 | 0.760 | 1 | 0.420 | |
| C/C | 2.41 (1.11–5.25) | 1.18 (0.41–3.38) | 1.63 (0.52–5.13) | |||||
| Log-additive | — | 1.44 (1.11–1.87) | 0.006* | 1.23 (0.90–1.69) | 0.2 | 1.62 (1.13–2.33) | 0.011* | |
| rs3976523 | Dominant | A/A | 1 | 0.071 | 1 | 0.066 | 1 | 0.047 |
| A/C-C/C | 1.31 (0.98–1.75) | 1.38 (0.98–1.94) | 0.66 (0.44–1.00) | |||||
| Recessive | A/A-A/C | 1 | 0.670 | 1 | 0.820 | 1 | 0.520 | |
| C/C | 1.10 (0.70–1.73) | 1.06 (0.62–1.82) | 1.23 (0.66–2.29) | |||||
| Log-additive | — | 1.19 (0.96–1.47) | 0.120 | 1.21 (0.94–1.56) | 0.140 | 0.83 (0.60–1.13) | 0.230 | |
| rs4240897 | Dominant | G/G | 1 | 0.011* | 1 | 0.029* | 1 | 0.015* |
| G/A-A/A | 0.69 (0.52–0.92) | 0.69 (0.49–0.96) | 0.60 (0.40–0.91) | |||||
| Recessive | G/G-G/A | 1 | 0.009* | 1 | 0.006* | 1 | 0.053 | |
| A/A | 0.50 (0.28–0.86) | 0.41 (0.20–0.82) | 0.45 (0.19–1.05) | |||||
| Log-additive | — | 0.70 (0.56–0.88) | 0.002* | 0.68 (0.52–0.89) | 0.004* | 0.63 (0.45–0.88) | 0.006* | |
| rs2236058 | Dominant | C/C | 1 | 0.150 | 1 | 0.082 | 1 | 0.086 |
| C/G-G/G | 1.84 (0.89–2.62) | 1.41 (0.95–2.10) | 1.96 (0.76–3.31) | |||||
| Recessive | C/C-C/G | 1 | 0.260 | 1 | 0.220 | 1 | 0.130 | |
| G/G | 1.46 (0.65–2.02) | 1.27 (0.87–1.84) | 1.43 (0.91–2.26) | |||||
| Log-additive | — | 1.44 (0.77–1.77) | 0.054 | 1.24 (0.98–1.56) | 0.072 | 1.45 (0.78–1.94) | 0.052 | |
| rs879255685 | Dominant | G/G | 1 | 0.610 | 1 | 0.860 | 1 | 0.720 |
| G/A-A/A | 1.08 (0.80–1.46) | 1.03 (0.73–1.46) | 1.08 (0.71–1.65) | |||||
| Recessive | G/G-G/A | 1 | 0.470 | 1 | 0.172 | 1 | 0.250 | |
| A/A | 1.38 (0.59–3.25) | 3.13 (0.94–7.01) | 1.91 (0.67–5.44) | |||||
| Log-additive | — | 1.10 (0.84–1.43) | 0.500 | 1.18 (0.88–1.59) | 0.280 | 1.14 (0.79–1.65) | 0.490 | |
| rs879255689 | Dominant | G/G | 1 | 0.230 | 1 | 0.023* | 1 | 0.045* |
| G/A-A/A | 1.21 (0.89–1.65) | 1.50 (1.06–2.12) | 1.55 (1.02–2.36) | |||||
| Recessive | G/G-G/A | 1 | 0.230 | 1 | 0.120 | 1 | 0.018* | |
| A/A | 1.71 (0.72–4.03) | 2.21 (0.84–5.80) | 3.46 (1.32–9.08) | |||||
| Log-additive | — | 1.22 (0.93–1.60) | 0.150 | 1.48 (1.09–2.01) | 0.013* | 1.60 (1.12–2.29) | 0.011* | |
Note: *p < 0.05 indicates statistical significance.
Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio; CI, confidence interval.