Table 3.
Multivariable Cox proportional hazards analysis for IgAN patients
| Factors | Odds ratio | 95% confidence Interval | P value | |
|---|---|---|---|---|
| Clinical background at Renal Biopsy | ||||
| History of Hypertension (presence to absence) | 1.39 | 0.68 | 2.85 | 0.37 |
| Mean arterial pressure (1 mmHg increase) | 1 | 0.98 | 1.02 | 0.76 |
| Age at renal biopsy (1 increase) | 1.01 | 0.98 | 1.03 | 0.57 |
| eGFR (ml/min/1.73m2) | 0.97 | 0.96 | 0.99 | < 0.01 |
| Urinary protein (g/day) by 1 increase | 1.17 | 1.04 | 1.31 | 0.01 |
| Familial History (Positive or Negative) | 2.31 | 1.1 | 4.85 | 0.03 |
| Renal biopsy findings | ||||
| MEST-C T score by 1 increase | 1 | 0.57 | 1.73 | 0.98 |
| Treatment Intervention | ||||
| Long-term prednisolone use | 1.85 | 0.94 | 3.64 | 0.08 |
| Use of RAS inhibitors | 2.65 | 0.61 | 11.5 | 0.19 |
The odds ratio and 95% confidence intervals are estimated using multivariable Cox proportional hazards analysis in IgA nephropathy patients (n = 389) who were followed up for more than two years. MEST-C scores are determined according to the Oxford classification [10]. Cellular/fibro-cellular crescents are scored as absent (C0), present in at least one glomerulus (C1), or present in > 25% of glomeruli (C2). eGFR, estimated glomerular filtration rate; RAS, renin angiotensin system; FH, familial history [of renal disease]. P values < 0.05 are boldfaced