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. Author manuscript; available in PMC: 2021 Jun 19.
Published in final edited form as: Cell Rep. 2019 Dec 24;29(13):4471–4481.e6. doi: 10.1016/j.celrep.2019.11.088

Figure 3. Vκ Gene Segments Harbor Unique, Evolutionarily Conserved Frss.

Figure 3.

(A) Conservation score of the region surrounding the Vκ RSS region. Top diagram shows the position of FR3 and CDR3 at the 3′ end of Vκ coding region. Heptamer (blue), spacer (purple and red), and nonamer (green) regions are highlighted.

(B) Number of V gene segments with FR3 with the last 3 codons encoded by nonamer-like sequences in the Igκ, Igh, Igl, Tra, Trb, Trd, and Trg loci.

(C) Number of V gene segments with CDR3 with length of 12 bp (red), 23 bp (blue), or other number of nucleotides (gray) in the Igκ, Igh, Igl, Tra, Trb, Trd, and Trg loci.

See also Figure S3. **p < 1e−10, Fisher’s test.