Fig. 4.

Validation of the MSRC to identify TNFi-exposed patients who are unlikely to respond to TNFi therapy. a Receiver operating characteristic curve for stratification of patients who are receiving a TNFi therapy based on achievement of CDAI remission or DAS28-CRP remission 3 months after test results. b Comparison of model scores for patients with or without a detected molecular signature of non-response. Boxes and intersecting line depict interquartile range and median, respectively. Bisecting colored lines indicate change in mean