Fig. 5.

Biology of inadequate response to TNFi therapies. The MSRC includes transcripts that encode proteins involved in many aspects of RA pathophysiology: innate immune response, cytokine biosynthesis, T and B cell homeostasis, bone homeostasis, the unfolded protein response, autophagy, apoptosis, and pro-inflammatory signaling. Detailed text and additional references can be found in the Supplemental Discussion