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Crosscommunication between signaling cascades. Both PI3K/Akt and MEK/ERK signaling pathways can inhibit the expression of proapoptotic proteins Bad and Bax and promote the survival and proliferation of hair cells. ROS can act on the p38 and JNK pathways through ASK-1 and promote the expression of proapoptotic proteins Bad and Bax to induce the apoptosis of hair cells.
