Table 1.
General characteristic of the entire population according to CD47 expression (positive vs. negative).
| Characteristics | Categories | ALL % (n) | CD47- % (n) | CD47+ % (n) | p value |
|---|---|---|---|---|---|
| (N = 51) | (N = 37) | (N = 14) | |||
| Gender | Female | 59 (30) | 66.7 (20) | 33.3 (10) | |
| Male | 41 (21) | 81 (17) | 19 (4) | 0.346 | |
| Median (±SD) | |||||
| Age | <60 years | 54.9 (28) | 82.1 (23) | 17.9 (5) | |
| ≥60 years | 45.1 (23) | 60.9 (14) | 39.1 (9) | 0.120 | |
| Smoking history | Nonsmoker | 39.2 (20) | 27.5 (14) | 30 (6) | |
| Smoker | 60.8 (31) | 77.5 (23) | 25.8 (8) | 0.758 | |
| ECOG PS | 0-1 | 78.4 (40) | 70 (28) | 30 (12) | |
| 2+ | 21.6 (11) | 81.8 (9) | 18.2 (2) | 0.705 | |
| Disease stage | IIIB | 27.5 (14) | 71.4 (10) | 28.6 (4) | |
| IV | 72.5 (37) | 73 (27) | 27 (10) | 1.0 | |
| Histological grade | Carcinoid | 15.7 (8) | 75 (6) | 25 (2) | |
| Atypical | 7.8 (4) | 75 (3) | 25 (1) | ||
| Large cells | 19.6 (10) | 60 (6) | 40 (4) | ||
| Small cells | 56.9 (29) | 75.9 (22) | 24.1 (7) | 0.804 | |
| Lung metastases | Absent | 88.2 (45) | 73.3 (33) | 26.7 (12) | |
| Present | 11.8 (6) | 66.7 (4) | 33.3 (2) | 0.661 | |
| Bone metastases | Absent | 84.3 (43) | 72.1 (31) | 27.9 (12) | |
| Present | 15.7 (8) | 75 (6) | 25 (2) | 1.0 | |
| Pleural effusion | Absent | 78.4 (40) | 67.5 (27) | 32.5 (13) | |
| Present | 21.6 (11) | 90.9 (10) | 9.1 (1) | 0.251 | |
| CNS metastases | Absent | 72.5 (37) | 73 (27) | 27 (10) | |
| Present | 27.5 (14) | 71.4 (10) | 28.6 (4) | 1.0 | |
| Liver metastases | Absent | 80.4 (41) | 68.3 (28) | 31.7 (13) | |
| Present | 19.6 (10) | 90 (9) | 10 (1) | 0.250 | |
| Adrenal metastases | Absent | 88.2 (45) | 73.3 (33) | 26.7 (12) | |
| Present | 11.8 (6) | 66.7 (4) | 33.3 (2) | 0.661 | |
| CD47 | Positive | 72.5 (37) | 0.771 | ||
| Negative | 27.5 (14) | ||||
| Ki-67 | 5-19% | 17.6 (9) | 77.8 (7) | 22.2 (2) | |
| 20-39% | 5.9 (3) | 66.7 (2) | 33.3 (1) | ||
| 40-80% | 19.6 (10) | 60 (6) | 40 (4) | ||
| 50-100% | 56.9 (29) | 75.9 (22) | 24.1 (7) |