Table 5.

In vivo Antitumor Efficacy and Safety Evaluation of St-Mc-DDS

St Type	St-Mc-DDS	Drug	Indication	Animal Model	Targeting Ability and Biodistribution	Tumor Volume	Tumor Mass	Body Weight	Ref.
pH	Polymer-drug conjugates	DOX	Breast cancer	Female BALB/c mice	Increased accumulation in tumors	3.1-fold smaller	54% TGI	Slow and steady increase	[81]
	Eph A10/TPP-DTX liposomes	Docetaxel	Breast cancer	Female BALB/c nude mice	Excellent targetability at tumor site	1.23-fold smaller	Higher tumor inhibition efficacy	Slightly increase	[42]
	CTPP-CSOSA/celastrol micelles	Celastrol	Breast cancer	Nude mice	Mainly concentrated in the liver and tumor, and increased in tumor as time prolonging	Smaller	80.17% TGI	An increase to a certain extent	[43]
	HER-2/DOX DQAsomes	DOX	Breast cancer	Nude mice bearing MCF-7/ADR model		Smaller	72.5% TGI	No obvious weight loss	[36]
	PEG-AIE-TPP micelles	AIE-TPP	Breast cancer	Athymic nude female mice	Better aggregation in tumor site	Much Smaller	Better tumor inhibition efficacy	Gradually increase	[44]
	HPMA-MSN/DTX nanoparticles	Docetaxel	Cervical cancer	HeLa cells tumor-bearing nude mice	Abundant tumor tissues accumulation	The growth of the tumors were suppressed	72.6% TGI	No obvious change	[45]
	TPP-Que-PEG nanoparticles	Quercetin	Liver cancer	H22 tumor-bearing Male ICR mice	High accumulation in tumor tissue	Smaller	65.7% TGI	Increase rate is similar to control group	[46]
	DSPE-KLA-DMA/PTX liposomes	Paclitaxel	Lung cancer	A549/Taxol cells xenografted onto nude mice	–	Smaller	86.7% TGI	No weight loss	[47]
	PDPA/TPGS/DOX micelles	DOX	Breast cancer	Nude mouse model bearing orthotopic tumor	Increased accumulation in tumors	3.5-fold smaller	3-fold less	No obvious weight loss	[48]
	HHG2C18 liposomes	Temsirolimus (CCI-779)	Renal cancer	Murine Renca cell xenograft models	Increased accumulation in tumors	Smaller	–	–	[49]
	CAT@S/Ce6-CTPP/DPEG	Catalase	Breast cancer	4T1 tumor model	Increased accumulation in tumors	Smaller	–	No obvious variation	[20]
Redox	Glucose-PEG-peptide-TPP-PAMAM-PTX conjugates	Paclitaxel	Breast cancer	MCF-7/ADR tumor-bearing nude mice	Increased accumulation in tumors	Smaller	84.27% TGI	Highest body weight increase	[78]
	TPP-OHA-S-S-Cur micelles	Curcumin	Breast cancer	–	–	–	–	–	[50]
	PLGA/C18-PEG-TPP/DLPE-S-S-mPEG/PTX nanoparticles	Paclitaxel	Breast cancer	MCF-7 tumor bearing BALB/c nude mice	High accumulation in tumor tissue	Smaller	90.5% TGI	No significant body weight loss	[51]
	TPP-PPa micelles	PPa	Breast cancer	–	–	–	–	–	[76]
Enzyme	HA/PEG/berberine derivative nanodrugs	Berberine derivative	Lung cancer	A549 tumor-bearing BALB/c nude mice	High accumulation at the tumor location	Smaller	61.7% TGI	No significant differences in body weight	[19]
	Non-isocyanate polyurethane-TPP/DOX nanocapsule	DOX	Brain cancer	Zebrafish embryo	–	–	–	–	[52]
	TPP-peptide nanoassemblies	TPP-peptide	Osteosarcoma cancer	–	–	–	–	–	[53]
Light	Perfluorooctyl bromide/IR780 liposomes	IR780	Breast cancer	4T1 tumor-bearing nude mice	The effective accumulation in tumor tissues	Smaller (complete tumor elimination)	Better tumor inhibition efficacy	Negligible weight fluctuations	[54]
	Iridium/Fe3O4 nanozyme	Iridium	Cervical cancer	HeLa tumor-bearing mice	–	Smaller	Better tumor inhibition efficacy	No significant body weight loss	[55]
	IR-780/DSPE-PEG2K-TPP liposomes	IR-780; Lonidamine	Lung cancer	LL/2 tumor-bearing mice	High accumulation in tumor tissue	Smaller (complete eradication)	Better tumor inhibition efficacy	A slight reduction	[56]
	AuNS-KLA-TPP/HA/DOX nanoparticles	DOX	Squamous carcinoma	SCC-7 tumor-bearing BALB/c nude mice	Effective tumor accumulation	Smaller	Better tumor inhibition efficacy	No obvious body weight reduction	[58]
	TPP/Ce6/PEG-/FA-PEG-Pt@Au nanoparticles	Ce6	Breast cancer	–	–	–	–	–	[59]
	PPa-NGO-mAb nanodrug	PPa	Brain cancer	–	–	–	–	–	[64]
	Yb/Tm/TiO2 nanoparticles	Yb/Tm/TiO2	Cervical cancer	Xenograft HeLa tumor models	–	Smaller (a much slower growth rate)	Good tumor growth inhibition efficacy	–	[65]
	TPP-coumarin-Fe3O4 nanoparticles	Fe3O4	Cervical cancer	A549 cell xenografted BALB/c nude mice	Accumulated at the tumor site	A more dramatic decrease	–	–	[66]
Magnetic field	DNA/PK-CP-SPION complexes	DNA	Cervical cancer	–	–	–	–	–	[69]

Abbreviations: DOX, doxorubicin; TGI, tumor growth inhibition.