Fig. 7.

Haloperidol (Halo) and clozapine (Cloz) reverse motor deficit in the CPZ mouse model. Following a 5-wk CPZ treatment, Haloperidol (Halo) or Clozapine (Cloz) (0.5 mg/kg) were administered intraperitoneal twice per week for 2 wk. Motor activity was evaluated in the rotarod (A and B) and bar test (C and D). The dark gray diamonds and bars represent control animals; the red circles and bars represent CPZ-treated animals; the purple diamonds and bars are naïve animals treated with Halo; the purple circles and bars are CPZ animals treated with Halo; the green diamonds and bars are naïve animals treated with Cloz; the green circles and bars are CPZ animals treated with Cloz. The data are means ± SEM of eight determinations per group. *P < 0.05, **P < 0.01, two-way ANOVA for repeated measures followed by the Bonferroni test.