Fig. 4.

Radiation-induced neoantigens are sufficient to sensitize KP9093.PADRE tumors to ICT. (A) Parental KP9093.PADRE lines ectopically expressing the indicated single, radiation-induced neoantigen were implanted subcutaneously into Rag2^−/− mice (red), immunocompetent WT mice (black), or anti–CTLA-4/anti–PD-1–treated WT mice (blue). Representative data are shown as individual tumor growth curves from one of two independent experiments; n = 5 per group. (B) Survival plots of the experiment described in A. *P < 0.05, **P < 0.005.