Table 3.
Cox proportional risk regression of BCSS among TNBC patients who underwent BCS or mastectomy
| Variable | Group | Reference | Local treatment | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|---|
| HR(95%CI) | P | HR(95%CI) | P | ||||
| Totala | BCS + RT | Mastectomy alone | 1.90(1.67–2.15) | 0.000 | 1.49(1.31–1.70) | 0.000 | |
| BCS + RT | Mastectomy+RT | 3.75(3.33–4.24) | 0.000 | 1.24(1.08–1.43) | 0.002 | ||
| Mastectomy alone | Mastectomy+RT | 1.98(1.77–2.22) | 0.000 | 0.83(0.74–0.94) | 0.003 | ||
| Ageb | < 45 | BCS + RT | Mastectomy alone | 1.56(1.19–2.06) | 0.001 | 1.44(1.09–1.91) | 0.010 |
| BCS + RT | Mastectomy+RT | 3.10(2.38–4.05) | 0.000 | 1.24(0.93–1.65) | 0.135 | ||
| Mastectomy alone | Mastectomy+RT | 1.99(1.61–2.44) | 0.000 | 0.86(0.69–1.07) | 0.186 | ||
| 45 ~ 54 | BCS + RT | Mastectomy alone | 1.75(1.38–2.21) | 0.000 | 1.50(1.18–1.90) | 0.001 | |
| BCS + RT | Mastectomy+RT | 3.61(2.87–4.53) | 0.000 | 1.21(0.94–1.56) | 0.145 | ||
| Mastectomy alone | Mastectomy+RT | 2.06(1.66–2.56) | 0.000 | 0.81(0.64–1.02) | 0.073 | ||
| 55 ~ 64 | BCS + RT | Mastectomy alone | 1.74(1.37–2.21) | 0.000 | 1.35(1.05–1.73) | 0.018 | |
| BCS + RT | Mastectomy+RT | 3.87(3.09–4.85) | 0.000 | 1.24(0.95–1.62) | 0.112 | ||
| Mastectomy alone | Mastectomy+RT | 2.22(1.75–2.81) | 0.000 | 0.92(0.71–1.19) | 0.522 | ||
| ≥65 | BCS + RT | Mastectomy alone | 2.79(2.15–3.62) | 0.000 | 1.87(1.42–2.47) | 0.000 | |
| BCS + RT | Mastectomy+RT | 4.73(3.60–6.21) | 0.000 | 1.35(0.98–1.86) | 0.066 | ||
| Mastectomy alone | Mastectomy+RT | 1.70(1.32–2.18) | 0.000 | 0.72(0.55–0.95) | 0.019 | ||
| Tumor sizec | T1 | BCS + RT | Mastectomy alone | 1.33(1.03–1.72) | 0.028 | 1.31(1.01–1.70) | 0.045 |
| BCS + RT | Mastectomy+RT | 3.67(2.74–4.91) | 0.000 | 1.40(1.00–1.96) | 0.048 | ||
| Mastectomy alone | Mastectomy+RT | 2.75(2.01–3.77) | 0.000 | 1.07(0.76–1.52) | 0.699 | ||
| T2 | BCS + RT | Mastectomy alone | 1.29(1.08–1.53) | 0.004 | 1.35(1.13–1.60) | 0.001 | |
| BCS + RT | Mastectomy+RT | 2.19(1.84–2.61) | 0.000 | 1.24(1.02–1.50) | 0.029 | ||
| Mastectomy alone | Mastectomy+RT | 1.71(1.44–2.03) | 0.000 | 0.92(0.76–1.11) | 0.374 | ||
| T3 | BCS + RT | Mastectomy alone | 2.41(1.63–3.54) | 0.000 | 2.00(1.35–2.97) | 0.001 | |
| BCS + RT | Mastectomy+RT | 2.19(1.51–3.17) | 0.000 | 1.58(1.08–2.31) | 0.018 | ||
| Mastectomy alone | Mastectomy+RT | 0.91(0.72–1.15) | 0.431 | 0.79(0.62–1.00) | 0.054 | ||
| T4 | BCS + RT | Mastectomy alone | 2.91(1.52–5.59) | 0.001 | 2.62(1.31–5.26) | 0.007 | |
| BCS + RT | Mastectomy+RT | 1.92(1.01–3.65) | 0.046 | 1.52(0.77–3.02) | 0.231 | ||
| Mastectomy alone | Mastectomy+RT | 0.66(0.51–0.86) | 0.002 | 0.58(0.44–0.76) | 0.000 | ||
| Lymph node statusd | N0 | BCS + RT | Mastectomy alone | 1.51(1.24–1.84) | 0.000 | 1.38(1.12–1.69) | 0.002 |
| BCS + RT | Mastectomy+RT | 2.81(2.13–3.69) | 0.000 | 1.63(1.19–2.24) | 0.002 | ||
| Mastectomy alone | Mastectomy+RT | 1.86(1.41–2.45) | 0.000 | 1.19(0.88–1.61) | 0.268 | ||
| N1 | BCS + RT | Mastectomy alone | 1.87(1.52–2.30) | 0.000 | 1.64(1.32–2.03) | 0.000 | |
| BCS + RT | Mastectomy+RT | 1.71(1.40–2.10) | 0.000 | 1.31(1.05–1.62) | 0.017 | ||
| Mastectomy alone | Mastectomy+RT | 0.92(0.76–1.10) | 0.359 | 0.80(0.66–0.96) | 0.018 | ||
| N2 | BCS + RT | Mastectomy alone | 1.67(1.19–2.35) | 0.003 | 1.30(0.91–1.85) | 0.156 | |
| BCS + RT | Mastectomy+RT | 1.33(0.99–1.79) | 0.058 | 1.05(0.77–1.44) | 0.753 | ||
| Mastectomy alone | Mastectomy+RT | 0.80(0.61–1.04) | 0.096 | 0.81(0.62–1.06) | 0.132 | ||
| N3 | BCS + RT | Mastectomy alone | 2.71(1.81–4.07) | 0.000 | 2.07(1.34–3.19) | 0.001 | |
| BCS + RT | Mastectomy+RT | 1.86(1.28–2.72) | 0.001 | 1.44(0.96–2.16) | 0.077 | ||
| Mastectomy alone | Mastectomy+RT | 0.69(0.53–0.89) | 0.005 | 0.70(0.53–0.91) | 0.008 | ||
Abbreviations: BCS breast-conserving surgery, RT radiotherapy, CI confidence interval, HR hazard ratio
aMultivariable analysis adjusted for age at diagnosis, ethnicity, marital status, laterality, primary tumor site, grade, tumor size and lymph node status
bMultivariable analysis adjusted for ethnicity, marital status, laterality, primary tumor site, grade, tumor size and lymph node status
cMultivariable analysis adjusted for age at diagnosis, ethnicity, marital status, laterality, primary tumor site, grade and lymph node status
dMultivariable analysis adjusted for age at diagnosis, ethnicity, marital status, laterality, primary tumor site, grade and tumor size