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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: J Clin Pharmacol. 2020 Sep 22;61(3):378–387. doi: 10.1002/jcph.1743

Figure 3.

Figure 3.

Simulated peak phenobarbital concentrations according to age (A) or the presence of RRT (C), and trough concentrations at 7 days according to age (B) or the presence of RRT (D). Estimated weights were: 3 kg for a 7-day-old neonate, 4 kg for a 2-month-old infant, and 5 kg for a 4-month-old infant. Maintenance dose simulations included a loading dose of 30 mg/kg in children without RRT and 40 mg/kg in children with RRT. The dotted lines represent goal concentrations between 20 and 40 mg/dL. RRT, renal replacement therapy.