Table 2.

Final model and bootstrap analysis¹

	Final Model				Bootstrap Analysis2
	Point Estimate	RSE (%)	95% CI	CV (%)	2.5th percentile	Median	97.5th percentile
CL (L/h) for a 3.4-kg neonate	0.038	11.9	0.03, 0.05		0.03	0.037	0.05
V (L/3.4 kg)	3.83	4.73	3.48, 4.18		3.50	3.83	4.21
TM50 on CL (days)	5.91	31.5	2.26, 9.56		1.84	5.96	12.30
RRT3 on CL	6.23	4.35	5.70, 6.76		4.71	7.97	17.60
Interindividual variability on CL	0.15	34.8	0.05, 0.25	38.9	0.04	0.14	0.24
Interindividual variability on V	0.07	24.3	0.04, 0.10	26.2	0.03	0.07	0.10
Residual variability4	0.01	26.8	0.006, 0.02	10.9	0.005	0.01	0.02

¹Parameter estimates are for a 3.4–kg neonate

²Bootstrap successful in 100% of runs

³Excluding slow continuous ultrafiltration

⁴Proportional error

CL (L/h)=0.038*(WT/3.4)^0.75*(AGE/(5.91+AGE)) *6.23 (if on RRT)

V (L)=3.83*(WT/3.4)

ALB: albumin, CL: clearance, CV: coefficient of variation, RRT: renal replacement therapy, RSE: relative standard error, TM50: age at which clearance reaches 50% of adult values, V: volume of distribution