Table 3.

Attainment of goal concentrations from simulations

Dose	Target attainment (%)	Concentrations1 (mg/L)
Goal: Peak concentration between 20–40 mg/L 2 hours post-dose
30 mg/kg	74.8%	26.7 ± 7.9
40 mg/kg	68.9%	35.7 ± 10.0
Goal: Trough concentration between 20–40 mg/L at 7 days
5 mg/kg/day	61.0%	23.6 ± 7.6
6 mg/kg/day	72.6%	26.4 ± 8.3
7 mg/kg/day	72.7%	29.9 ± 9.1
Goal: Trough concentration between 20–40 mg/L at 20 days
5 mg/kg/day	49.6 %	22.7 ± 9.4
6 mg/kg/day	59.0 %	26.4 ± 10.7
7 mg/kg/day	59.5 %	31.2 ± 12.8
On renal replacement therapy
Goal: Peak concentration between 20–40 mg/L 2 hours post-dose
30 mg/kg	72.0%	24.6 ± 6.5
40 mg/kg	76.1%	32.7 ± 9.0
Goal: Trough concentration between 20–40 mg/L at 7 days
45 mg/kg/day given as divided doses q12h	50.4%	27.6 ± 14.4
45 mg/kg/day given as divided doses q8h	52.3%	31.1 ± 15.4
40 mg/kg/day given as divided doses q6h	57.1%	28.2 ± 12.7

¹Mean value ± SD