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. 2021 Jun 20;11(6):e429. doi: 10.1002/ctm2.429

FIGURE 8.

FIGURE 8

A schematic presentation of IRF2/HHAS1/miR‐204‐5p/RUNX2 axis on BMSC osteogenic differentiation. Under osteogenic induction, increased IRF2 promotes the transcription of HHAS1. Subsequently, HHAS1 sponges miR‐204‐5p and protects RUNX2 mRNA from translation inhibition, therefore mediating enhanced RUNX2 protein production and accelerating osteogenic differentiation