Table 6.

Brain areas with significantly (p < 0.0017) greater deactivations with sham compared to non-invasive cervical vagal nerve stimulation nVNS during the first (TSB1), second (TSB2), and third (TSB3) exposures to personalized trauma as measured with positron emission tomography. Significant clusters are presented by size (number of voxels) and location (Brodmann area, cluster peak Talairach coordinates). Sub-cluster peaks are also identified. ND = no difference.

Voxel Number	Brain Region	Brodmann Area	Talairach			Z Score
			X	Y	Z
TSB1
64	R Temporal Lobe, Fusiform Gyrus	37	40	−57	−6	4.66
	R Temporal Lobe, Fusiform Gyrus	37	46	−51	−9	3.12
33	R Parahippocampal Gyrus	30	10	−39	0	4.52
60	R Frontal Lobe, Inferior Gyrus	46	34	17	24	4.44
32	R Parietal Lobe, Postcentral Gyrus	43	63	−11	16	4.27
37	R Limbic Lobe, Posterior Cingulate	30	14	−50	12	4.25
25	L Frontal Lobe, Precentral Gyrus	9	−32	4	35	4.25
25	L Anterior Cingulate	32	−10	32	10	4.14
16	R Posterior Cingulate	30	24	−70	8	3.99
17	R Occipital Lobe, Cuneus	18	12	−71	20	3.75
12	L Frontal Lobe, Inferior Gyrus	45	−53	11	23	3.72
28	L Posterior Cingulate	31	−14	−41	32	3.57
14	R Occipital Lobe, Cuneus	18	16	−84	21	3.56
14	L Temporal Lobe, Middle Gyrus	37	−42	−60	1	3.35
14	R Occipital Lobe, Inferior Gyrus	37	44	−66	−2	3.34
13	R Occipital Lobe, Inferior Gyrus	19	36	−78	−6	3.30
11	R Insula	13	38	−24	20	3.27
TSB2
43	R Frontal Lobe, Precentral Gyrus	6	50	−2	7	4.58
15	L Parietal Lobe, Precuneus	7	−4	−33	45	4.58
13	R Occipital Lobe, Middle Gyrus	19	32	−90	18	4.55
25	R Insula	13	48	−24	21	4.45
	R Parietal Lobe, Postcentral Gyrus	40	57	−26	23	3.24
49	L Frontal Lobe, Middle Gyrus	6	−26	−9	63	4.29
	L Frontal Lobe, Superior Gyrus	6	−18	−6	66	4.00
11	R Insula	13	38	−9	16	4.18
16	L Cerebellum		−32	−45	−16	4.05
14	R Frontal Lobe, Medial Gyrus	10	16	51	6	4.02
14	R Frontal Lobe, Superior Gyrus	6	24	7	58	3.94
13	L Cerebellum		−2	−78	−11	3.91
14	L Frontal Lobe, Superior Gyrus	6	−18	14	56	3.91
14	R Frontal Lobe, Precentral Gyrus	44	63	8	11	3.89
	R Frontal Lobe, Inferior Gyrus	9	67	11	18	3.60
13	L Temporal Lobe, Superior Gyrus	39	−46	−48	11	3.59
11	R Frontal Lobe, Middle Gyrus	9	38	35	35	3.59
14	L Insula	13	−34	6	8	3.56
12	R Thalamus		8	−7	10	3.31
TSB3
18	L Frontal Lobe, Superior Gyrus	10	−16	51	18	4.57
15	L Frontal Lobe, Middle Gyrus	9	−42	11	35	4.46
18	R Temporal Lobe, Superior Gyrus	38	48	18	−21	4.37
20	R Cerebellum		30	−30	−22	4.34
26	R Frontal Lobe, Medial Gyrus	10	14	45	3	4.21
22	L Occipital Lobe, Precuneus	31	−2	−67	20	3.99
14	R Anterior Cingulate	32	10	35	7	3.76
13	R Frontal Lobe, Inferior Gyrus	47	57	33	−5	3.44
	R Frontal Lobe, Inferior Gyrus	47	61	21	−3	3.18