Fig. 2.
The definition of the spherical space used in the survival probability calculation. The transparent grey space was defined as the sphere whose center was positioned at the average coordinates of H41, H164, and D187 and whose radius was 5 Å. This depicted structure was taken from the PDB ID 6WQF [19]. The symbol Oin indicates an oxygen atom of a water molecule within the sphere. The water molecule is surrounded by H41, H164, and D187 and corresponds to the crystal water that are considered important for the catalytic activity [19],[45].