Table 2.
Summary estimates for the odds ratio (OR) in various allele/genotype contrasts, the significance level (p value) of heterogeneity test (Q test), and the I2 metric: overall analysis
| Genetic Models | Fixed effect OR (95% CI), p | Random effect OR (95% CI), p | Heterogeneity p-value (Q test) | I2 (%) | Publication bias (p of Egger’s test) |
|---|---|---|---|---|---|
| Total 18 studies | |||||
| Allele Contrast (A vs. G) | 1.007(0.93–1.09),0.84 | 1.02(0.90–1.14),0.03 | 0.004 | 52.69 | 0.55 |
| Co-dominant (AG vs. GG) | 0.98(0.86–1.11),0.80 | 0.97(0.86–1.11),0.71 | 0.49 | 0 | 0.21 |
| Homozygote (AA vs. GG) | 1.03(0.87–1.21),0.71 | 1.06(0.81–1.38),0.69 | 0.001 | 56.17 | 0.63 |
| Dominant (AA + AG vs. GG) | 0.98(0.87–1.10),0.76 | 0.99(0.85–1.14),0.87 | 0.13 | 27.35 | 0.08 |
| Recessive ( AA vs. GG + AG) | 1.4(0.91–1.20),0.49 | 1.05(0.85–1.29),0.61 | 0.01 | 48.5 | 0.76 |