Table 4.
Significant associations of HLA alleles and haplotypes in Swedish EOMG AChR-antibody positive cases and controls ranked by odds ratios.
| HLA Locus | HLA alleles/haplotypes | EOMG Cases | Controls | OR | 95% CI | P-value | P_adj | Effect | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Count | Fq | Count | Fq | |||||||
| B~C | B*08:01~C*07:01 | 75 | 0.341 | 456 | 0.108 | 4.29 | 3.15–5.81 | <2.22e−16 | Risk | |
| B | B*08:01 | 76 | 0.345 | 469 | 0.111 | 4.24 | 3.12–5.74 | <2.22e−16 | Risk | |
| B~DRB1 | B*08:01~DRB1*03:01 | 62 | 0.282 | 387 | 0.091 | 3.91 | 2.81–5.38 | <2.22e−16 | Risk | |
| A~B~C | A*01:01~B*08:01~C*07:01 | 55 | 0.250 | 347 | 0.082 | 3.74 | 2.65–5.21 | <2.22e−16 | Risk | |
| A~B | A*01:01~B*08:01 | 55 | 0.250 | 350 | 0.083 | 3.70 | 2.63–5.16 | <2.22e−16 | Risk | |
| A~C | A*01:01~C*07:01 | 56 | 0.255 | 375 | 0.088 | 3.52 | 2.50–4.89 | 4.29E−16 | Risk | |
| C | C*07:01 | 81 | 0.368 | 603 | 0.142 | 3.51 | 2.60–4.72 | <2.22e−16 | Risk | |
| DQB1~DRB1 | DQB1*02:01G~DRB1*03:01 | 65 | 0.295 | 519 | 0.122 | 3.01 | 2.18–4.10 | 1.18E−13 | Risk | |
| DRB1 | DRB1*03:01 | 65 | 0.295 | 522 | 0.123 | 2.99 | 2.17–4.08 | 1.68E−13 | Risk | |
| A | A*01:01 | 63 | 0.286 | 596 | 0.141 | 2.45 | 1.78–3.35 | 2.82E−09 | Risk | |
| All | A*01:01~B*08:01~C*07:01~DPB1*04:01~DQB1*02:01G~DRB1*03:01 | 18 | 0.082 | 151 | 0.036 | 2.41 | 1.36–4.04 | 4.66E−04 | Risk | |
| DQB1 | DQB1*02:01G | 68 | 0.309 | 757 | 0.179 | 2.06 | 1.51–2.79 | 1.16E−06 | Risk | |
| DPB1 | DPB1*01:01 | 23 | 0.105 | 234 | 0.055 | 2.00 | 1.21–3.16 | 2.19E−03 | 0.013 | Risk |
| DPB1 | DPB1*04:01 | 84 | 0.382 | 1909 | 0.450 | 0.75 | 0.56–1.00 | 0.047 | 0.279 | NS |
| C | C*05:01 | 10 | 0.045 | 353 | 0.083 | 0.52 | 0.25–1.00 | 0.046 | Protective | |
| DQB1 | DQB1*05:01 | 14 | 0.064 | 511 | 0.121 | 0.50 | 0.26–0.86 | 0.011 | Protective | |
| DQB1~DRB1 | DQB1*05:01~DRB1*01:01 | 10 | 0.045 | 407 | 0.096 | 0.45 | 0.21–0.85 | 0.012 | Protective | |
| DRB1 | DRB1*01:01 | 10 | 0.045 | 411 | 0.097 | 0.44 | 0.21–0.84 | 0.011 | Protective | |
| DRB1 | DRB1*07:01 | 6 | 0.027 | 333 | 0.079 | 0.33 | 0.12–0.74 | 5.15E−03 | Protective | |
| DQB1~DRB1 | DQB1*02:01~DRB1*07:01 | 3 | 0.014 | 231 | 0.054 | 0.24 | 0.05–0.72 | 8.07E−03 | Protective | |
EOMG, early-onset Myasthenia Gravis; Fq, frequency; OR, odds ratio; CI, confidence interval; Effect, effect of haplotype on disease outcome. NS, not significant.