Table 5.
Significant associations of HLA alleles and haplotypes in Italian LOMG AChR-antibody positive cases and controls ranked by odds ratios.
| HLA Locus | HLA alleles/haplotypes | LOMG Cases | Controls | OR | 95% CI | P-value | P_adj | Effect | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Count | Fq | Count | Fq | |||||||
| DQA1~DRB1 | DQA1*01:02:01:01SG~DRB1*15:01:01:01SG | 12 | 0.102 | 14 | 0.031 | 3.56 | 1.45–8.54 | 9.94E−04 | Risk | |
| DRB1~DRB345 | DRB1*15:01:01:01SG~DRB5*01:01:01 | 14 | 0.119 | 17 | 0.037 | 3.46 | 1.52–7.71 | 5.19E−04 | Risk | |
| DRB1 | DRB1*15:01:01:01SG | 14 | 0.119 | 17 | 0.037 | 3.46 | 1.52–7.71 | 5.19E−04 | 4.67E−03 | Risk |
| DQA1 | DQA1*01:02:01:01SG | 14 | 0.119 | 17 | 0.037 | 3.46 | 1.52–7.71 | 5.19E−04 | Risk | |
| DRB345 | DRB5*01:01:01 | 14 | 0.119 | 18 | 0.040 | 3.26 | 1.45–7.18 | 8.79E−04 | Risk | |
| DPA1~DPB1 | DPA1*01:03:01:02~DPB1*02:01:02 | 10 | 0.085 | 17 | 0.037 | 2.38 | 0.94–5.68 | 0.031 | Risk | |
| DQB1~DRB1 | DQB1*02:02:01:01~DRB1*07:01:01:01SG | 16 | 0.136 | 32 | 0.070 | 2.07 | 1.02–4.05 | 0.023 | Risk | |
| DQB1 | DQB1*02:02:01:01 | 17 | 0.144 | 35 | 0.077 | 2.01 | 1.01–3.86 | 0.024 | Risk | |
| DQA1~DQB1 | DQA1*02:01:01:01SG~DQB1*02:02:01:01 | 16 | 0.136 | 33 | 0.073 | 2.00 | 0.99–3.91 | 0.030 | Risk | |
| DQA1~DRB1 | DQA1*02:01:01:01SG~DRB1*07:01:01:01SG | 17 | 0.144 | 38 | 0.084 | 1.84 | 0.93–3.50 | 0.048 | Risk | |
| DRB1 | DRB1*07:01:01:01SG | 17 | 0.144 | 38 | 0.084 | 1.84 | 0.93–3.50 | 0.048 | Risk | |
| DRB345 | DRB3*01:01:02:01/02 | 5 | 0.042 | 54 | 0.119 | 0.33 | 0.10–0.84 | 0.015 | Protective | |
| DQA1~DRB1 | DQA1*01:03:01:02SG~DRB1*13:01:01:01SG | 1 | 0.008 | 27 | 0.059 | 0.14 | 0.00–0.84 | 0.022 | Protective | |
| DQB1~DRB1 | DQB1*06:03:01~DRB1*13:01:01:01SG | 1 | 0.008 | 27 | 0.059 | 0.14 | 0.00–0.84 | 0.022 | Protective | |
| DQA1~DQB1 | DQA1*01:03:01:02SG~DQB1*06:03:01 | 1 | 0.008 | 27 | 0.059 | 0.14 | 0.00–0.84 | 0.022 | Protective | |
| DQA1 | DQA1*01:03:01:02SG | 1 | 0.008 | 27 | 0.059 | 0.14 | 0.00–0.84 | 0.022 | Protective | |
| DRB1 | DRB1*13:01:01:01SG | 1 | 0.008 | 30 | 0.066 | 0.12 | 0.00–0.74 | 0.014 | 0.124 | NS |
| A | A*24:02:01:01 | 4 | 0.034 | 57 | 0.126 | 0.24 | 0.06–0.68 | 4.06E−03 | Protective | |
LOMG, late-onset Myasthenia Gravis; Fq, frequency; OR, odds ratio; CI, confidence interval; P_adj, Bonferroni corrected P-values, Only HLA-DRB1 alleles were corrected; Effect, effect of haplotype on disease outcome. NS, not significant.