Table 6.
Significant associations of HLA alleles and haplotypes in Norwegian LOMG AChR-antibody positive cases and controls ranked by odds ratios.
| HLA Locus | HLA alleles/haplotypes | LOMG Cases | Controls | OR | 95% CI | P-value | P_adj | Effect | ||
|---|---|---|---|---|---|---|---|---|---|---|
| Count | Fq | Count | Fq | |||||||
| All loci | A*03:01:01:01~B*07:02:01~C*07:02:01:03~DPA1*01:03:01:02~DPB1*04:01:01:01~DQA1*01:02:01:01SG~ DQB1*06:02:01~DRB1*15:01:01:01SG~DRB5*01:01:01 | 12 | 0.055 | 17 | 0.018 | 3.23 | 1.38–7.30 | 1.30E−03 | 0.004 | Risk |
| B~DRB1 | B*07:02:01~DRB1*15:01:01:01SG | 37 | 0.168 | 90 | 0.093 | 1.98 | 1.27–3.04 | 1.08E−03 | 0.009 | Risk |
| DQA1~DRB1 | DQA1*01:02:01:01SG~DRB1*15:01:01:01SG | 54 | 0.245 | 145 | 0.149 | 1.85 | 1.27–2.67 | 5.74E−04 | 0.007 | Risk |
| DRB1~DRB345 | DRB1*15:01:01:01SG~DRB5*01:01:01 | 54 | 0.245 | 146 | 0.151 | 1.84 | 1.26–2.64 | 6.74E−04 | 0.009 | Risk |
| DRB1 | DRB1*15:01:01:01SG | 54 | 0.245 | 146 | 0.151 | 1.84 | 1.26–2.64 | 6.74E−04 | Risk | |
| DQA1 | DQA1*01:02:01:01SG | 55 | 0.250 | 150 | 0.155 | 1.82 | 1.26–2.62 | 7.20E−04 | Risk | |
| DRB345 | DRB5*01:01:01 | 54 | 0.245 | 148 | 0.153 | 1.81 | 1.24–2.60 | 9.23E−04 | 0.008 | Risk |
| DQ~DRB | DQA1*01:02:01:01SG~DQB1*06:02:01~DRB1*15:01:01:01SG~ DRB5*01:01:01 | 52 | 0.236 | 144 | 0.148 | 1.78 | 1.21–2.57 | 1.50E−03 | 0.021 | Risk |
| DQB1~DRB1 | DQB1*06:02:01~DRB1*15:01:01:01SG | 52 | 0.236 | 145 | 0.149 | 1.76 | 1.20–2.55 | 1.75E−03 | Risk | |
| DQA1~DQB1 | DQA1*01:02:01:01SG~DQB1*06:02:01 | 52 | 0.236 | 145 | 0.149 | 1.76 | 1.20–2.55 | 1.75E−03 | Risk | |
| DQB1 | DQB1*06:02:01 | 52 | 0.236 | 146 | 0.151 | 1.75 | 1.20–2.52 | 2.02E−03 | Risk | |
| B | B*07:02:01 | 50 | 0.227 | 147 | 0.152 | 1.65 | 1.12–2.39 | 6.36E−03 | 0.064 | NS |
| B~C | B*07:02:01~C*07:02:01:03 | 49 | 0.223 | 146 | 0.151 | 1.62 | 1.10–2.35 | 8.99E−03 | 0.090 | NS |
| C | C*07:02:01:03 | 49 | 0.223 | 150 | 0.155 | 1.57 | 1.07–2.27 | 0.015 | 0.160 | NS |
| DPA1~DPB1 | DPA1*01:03:01:04~DPB1*04:01:01:01 | 43 | 0.195 | 133 | 0.137 | 1.53 | 1.02–2.26 | 0.028 | 0.167 | NS |
| DPA1 | DPA1*01:03:01:04 | 49 | 0.223 | 154 | 0.159 | 1.52 | 1.03–2.20 | 0.023 | 0.159 | NS |
| DQA1~DQB1 | DQA1*02:01:01:01SG~DQB1*02:02:01:01 | 23 | 0.105 | 51 | 0.053 | 2.10 | 1.20–3.60 | 3.95E−03 | Risk | |
| DQB1~DRB1 | DQB1*02:02:01:01~DRB1*07:01:01:01SG | 23 | 0.105 | 51 | 0.053 | 2.10 | 1.20–3.60 | 3.95E−03 | Risk | |
| DQB1 | DQB1*02:02:01:01 | 23 | 0.105 | 51 | 0.053 | 2.10 | 1.20–3.60 | 3.95E−03 | Risk | |
| DQ~DRB | DQA1*02:01:01:01SG~DQB1*02:02:01:01~ DRB1*07:01:01:01SG~DRB4*01:03:01:01/03 | 12 | 0.055 | 27 | 0.028 | 2.01 | 0.91–4.19 | 0.045 | 0.624 | NS |
| DRB1~DRB345 | DRB1*07:01:01:01SG~DRB4*01:03:01:01/03 | 12 | 0.055 | 27 | 0.028 | 2.01 | 0.91–4.19 | 0.045 | 0.579 | NS |
| DQB1~DRB1 | DQB1*02:01:01~DRB1*03:01:01:01SG | 19 | 0.086 | 131 | 0.135 | 0.61 | 0.34–1.01 | 0.049 | Protective | |
| DQB1 | DQB1*02:01:01 | 19 | 0.086 | 132 | 0.136 | 0.60 | 0.34–1.00 | 0.045 | Protective | |
| DRB1 | DRB1*03:01:01:01SG | 19 | 0.086 | 132 | 0.136 | 0.60 | 0.34–1.00 | 0.045 | Protective | |
| DRB345 | DRB3*01:01:02:01/02 | 20 | 0.091 | 161 | 0.166 | 0.50 | 0.29–0.83 | 5.12E−03 | 0.046 | Protective |
| DRB345 | DRB3*02:02:01:02 | 7 | 0.032 | 71 | 0.073 | 0.42 | 0.16–0.92 | 0.025 | 0.226 | NS |
| DQB1 | DQB1*06:03:01 | 4 | 0.018 | 64 | 0.066 | 0.26 | 0.07–0.72 | 5.82E−03 | Protective | |
| DQA1~DRB1 | DQA1*01:03:01:02SG~DRB1*13:01:01:01SG | 3 | 0.014 | 64 | 0.066 | 0.20 | 0.04–0.61 | 2.36E−03 | 0.028 | Protective |
| DRB1 | DRB1*13:01:01:01SG | 3 | 0.014 | 64 | 0.066 | 0.20 | 0.04–0.61 | 2.36E−03 | Protective | |
| DQB1~DRB1 | DQB1*06:03:01~DRB1*13:01:01:01SG | 3 | 0.014 | 64 | 0.066 | 0.20 | 0.04–0.61 | 2.36E−03 | Protective | |
| DQA1~DQB1 | DQA1*01:03:01:02SG~DQB1*06:03:01 | 3 | 0.014 | 64 | 0.066 | 0.20 | 0.04–0.61 | 2.36E−03 | Protective | |
| DQA1 | DQA1*01:03:01:02SG | 3 | 0.014 | 65 | 0.067 | 0.19 | 0.04–0.60 | 2.08E−03 | Protective | |
| DQ~DRB | DQA1*01:03:01:02SG~DQB1*06:03:01~DRB1*13:01:01:01SG~ DRB3*01:01:02:01/02 | 1 | 0.005 | 33 | 0.034 | 0.13 | 0.00–0.78 | 0.018 | 0.250 | NS |
| DRB1~DRB345 | DRB1*13:01:01:01SG~DRB3*01:01:02:01/02 | 1 | 0.005 | 33 | 0.034 | 0.13 | 0.00–0.78 | 0.018 | 0.232 | NS |
LOMG, late-onset Myasthenia Gravis; Fq, frequency; OR, odds ratio; CI, confidence interval; P_adj, Bonferroni corrected P-values, P-values for HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DQA1~HLA-DQB1, and HLA-DQB1~HLA-DRB1 alleles were not corrected for multiple comparisons; Effect, effect of haplotype on disease outcome. NS, not significant.