Table 3.
Hematology results of male (M) rats. Group mean values and standard deviation (SD).
| Hematology | Units | Groups of male rats (dose level in mg TOS/kg bw/day) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 1M (0) |
2M (110.3) |
3M (363.8) |
4M (1102.5) |
||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| Hct | L/L | 0.496 | (0.0191) | 0.480 | (0.0214) | 0.476 | (0.0185) | 0.473∗ | (0.0267) |
| Hb | g/dL | 16.6 | (0.45) | 16.4 | (0.52) | 16.4 | (0.73) | 16.2 | (0.67) |
| RBC | ×1012/L | 9.18 | (0.331) | 8.81 | (0.435) | 8.80 | (0.395) | 8.72∗ | (0.492) |
| Retic | ×1012/L | 0.140 | (0.0280) | 0.153 | (0.0165) | 0.143 | (0.0166) | 0.161 | (0.0213) |
| MCH | Pg | 18.1 | (0.38) | 18.6 | (0.92) | 18.6 | (0.67) | 18.6 | (0.84) |
| MCHC | g/dL | 33.4 | (0.82) | 34.2 | (0.94) | 34.5 | (0.92) | 34.2 | (1.10) |
| MCV | fL | 54.1 | (0.54) | 54.6 | (2.12) | 54.1 | (1.12) | 54.3 | (1.32) |
| RDW | % | 11.5 | (0.43) | 11.4 | (0.36) | 11.5 | (0.58) | 11.6 | (0.61) |
| WBC | ×109/L | 7.11 | (1.718) | 6.20 | (1.536) | 7.21 | (0.882) | 5.81 | (1.234) |
| Neut | ×109/L | 1.31 | (0.418) | 1.34 | (0.483) | 1.35 | (0.388) | 0.91 | (0.324) |
| Lym | ×109/L | 5.49 | (1.328) | 4.60 | (1.519) | 5.55 | (0.778) | 4.65 | (1.030) |
| Eos | ×109/L | 0.09 | (0.043) | 0.09 | (0.032) | 0.08 | (0.037) | 0.09 | (0.021) |
| Baso | ×109/L | 0.02 | (0.015) | 0.02 | (0.009) | 0.03 | (0.012) | 0.02 | (0.011) |
| Mono | ×109/L | 0.14 | (0.037) | 0.11 | (0.049) | 0.15 | (0.055) | 0.10 | (0.039) |
| LUC | ×109/L | 0.06 | (0.017) | 0.05 | (0.021) | 0.06 | (0.021) | 0.04 | (0.016) |
| Plat | ×109/L | 670 | (82.7) | 634 | (54.6) | 642 | (82.6) | 650 | (80.7) |
| PT | sec | 19.6 | (1.10) | 19.3 | (1.55) | 19.5 | (1.38) | 18.8 | (0.75) |
| APTT | sec | 16.7 | (1.77) | 17.7 | (3.46) | 18.4 | (1.41) | 18.0 | (2.32) |
Significantly different from the controls: ∗: P < 0.05; ∗∗: P < 0.01.
Hct: Hematocrit; Hb: Hemoglobin; RBC: Total Red Blood Cell; Retic: Absolute Reticulocytes Count; MCH: Mean Cell Hemoglobin; MCHC: Mean Cell Hemoglobin Concentration; MCV: Mean Cell Volume; RDW: Red Cell distribution Width; WBC: Total Leukocyte Count; Neut: Neutrophils; Lym: Lymphocytes; Eos: Eosinophils; Baso: Basophils; Mono: Monocytes; LUC: Large unstained cels; Plat: Platelet Count; PT: Prothrombin Time; APTT: Activated partial thromboplastin time.