Table 5.
Clinical chemistry results of male (M) rats. Group mean values and standard deviation (SD).
| Clinical chemistry | Units | Groups of male rats (dose level in mg TOS/kg bw/day) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 1M (0) |
2M (110.3) |
3M (363.8) |
4M (1102.5) |
||||||
| Mean | SD | Mean | SD | Mean | SD | Mean | SD | ||
| ALP | U/L | 84 | (13.5) | 83 | (20.1) | 77 | (13.6) | 73 | (13.6) |
| ALT | U/L | 56 | (14.2) | 62 | (25.6) | 49 | (9.3) | 50 | (6.9) |
| AST | U/L | 88 | (34.4) | 103 | (57.8) | 78 | (21.8) | 89 | (27.6) |
| Bi Ac | μmol/L | 35.0 | (8.65) | 26.6 | (12.16) | 29.6 | (8.80) | 19.6∗∗ | (8.67) |
| Urea | mmol/L | 6.66 | (1.044) | 7.23 | (0.859) | 6.40 | (0.883) | 6.57 | (1.292) |
| BUN | mmol/L | 6.66 | (1.044) | 7.23 | (0.859) | 6.40 | (0.883) | 6.57 | (1.292) |
| Creat | μmol/L | 24 | (2.8) | 26 | (3.0) | 25 | (2.8) | 26 | (2.3) |
| Gluc | mmol/L | 7.69 | (1.588) | 9.10 | (1.339) | 8.37 | (1.948) | 7.81 | (1.327) |
| Chol | mmol/L | 2.29 | (0.444) | 2.39 | (0.255) | 2.27 | (0.397) | 2.35 | (0.348) |
| HDL | mmol/L | 1.72 | (0.330) | 1.76 | (0.214) | 1.68 | (0.294) | 1.73 | (0.229) |
| LDL | mmol/L | 0.25 | (0.084) | 0.28 | (0.088) | 0.28 | (0.086) | 0.25 | (0.072) |
| Na | mmol/L | 142 | (1.0) | 142 | (1.5) | 142 | (1.2) | 142 | (0.8) |
| K | mmol/L | 4.06 | (0.193) | 4.09 | (0.384) | 4.00 | (0.306) | 3.98 | (0.237) |
| Total Prot | g/L | 68 | (2.3) | 69 | (2.9) | 69 | (3.9) | 70 | (3.2) |
| Alb | g/L | 40 | (1.1) | 40 | (1.4) | 40 | (1.3) | 40 | (1.0) |
| A/G | Ratio | 1.45 | (0.137) | 1.40 | (0.137) | 1.35 | (0.172) | 1.35 | (0.096) |
Significantly different from the controls: ∗: P < 0.05; ∗∗: P < 0.01.
ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; Bi Ac: Bile acids – total; BUN: Blood urea nitrogen; Crea: Creatinine; Gluc: Glucose; Chol: Total cholesterol; HDL: High density lipoprotein; LDL: High density lipoprotein; Na: Sodium; K: Potassium; Total Prot: Total protein; Alb: Albumin and A/G: Albumin/globulin ratio.