Table 3.

Pediatric localized scleroderma vs. healthy control comparison identifies gene enrichment groups of interest relating to inflammatory and regulatory signatures.

function	Gene symbol	Gene description	Relative expression
Inflammatory response			Log2FoldChange	p-value
	CXCL11	C–X–C motif chemokine 11	7.16	0.0000
	IL12B	Interleukin-12 subunit beta: cytokine, defense/immunity protein	5.32	0.0014
	CXCL10	C–X–C motif chemokine 10	3.12	0.0014
	SELE	E-selectin	3.05	0.0000
	MSR1	Macrophage scavenger receptor types I and I: oxidase, receptor, serine protease	2.52	0.0015
KRAS signaling
	IFNG	Interferon gamma	4.24	0.0011
	SLC6A3	Sodium-dependent dopamine transporter: cation transporter	2.91	0.0173
	MAGIX	PDZ domain-containing protein	2.84	0.0017
	KRT1	Keratin, type II cytoskeletal 1	2.67	0.0000
	CPA2	Carboxypeptidase A2: metalloprotease	−7.73	0.0000
Epithelial–mesenchymal transition
	TGM2	Protein-glutamine gamma-glutamyltransferase 2: acyltransferase	−2.47	0.0014
	IGFBP2	Insulin-like growth factor-binding protein 2: protease inhibitor	−2.57	0.0001
	GREM1	Gremlin-1	−2.57	0.0002
	WNT5A	Protein Wnt-5a: signaling molecule	−2.60	0.0004
	CXCL6	C–X–C motif chemokine 6	−3.29	0.0017
	CDH2	Cadherin-2	−3.40	0.0000
	PRSS2	Trypsin-2: serine protease	−6.83	0.0000
Leukocyte mediation and migration
	IGKV1-17	Immunoglobulin kappa variable 1–17	9.88	0.0000
	IGKV2D-29	Immunoglobulin kappa variable 2D−29	9.64	0.0002
	IGHV1-3	Immunoglobulin heavy variable 1–3	8.79	0.0011
	IGKV1-16	Immunoglobulin kappa variable 1–16	8.70	0.0000
	IGKV1D-12	Immunoglobulin kappa variable 1D−12	6.94	0.0000
	SLC7A10	Asc-type amino acid transporter 1	6.74	0.0000
	LEP	Leptin	5.69	0.0000
	IGKV2-24	Immunoglobulin kappa variable 2–24	5.03	0.0000
	CD244	Natural killer cell receptor 2B4: cell adhesion molecule, immunoglobulin receptor superfamily, membrane-bound signaling molecule, protein kinase	4.16	0.0000
	IL36G	Interleukin-36 gamma	3.29	0.0002
	RAET1L	UL16-binding protein 6	3.13	0.0004