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. 2021 Jun 7;15:668616. doi: 10.3389/fnins.2021.668616

FIGURE 3.

FIGURE 3

Effect of EA applied at different acupoints on day 0 without IS injection and day 8 (1 day after the 4th IS injection) among Con, IS, IS + SEA, GB20 + GB34, GB20 + SJ17, and GB34 + ST36 groups. Changes in mechanical [50% FMWT (A,B), and 50% PMWT (C,D)] and thermal [TFL (E), HPL (F), and CPB (G)] hyperalgesia in dural aCSF- and IS-injected rats that received four times EA at GB20 + GB34, GB20 + SJ17, GB34 + ST36, or non-acupoints every other day (n = 10). One-way ANOVA followed by post hoc Tukey test. Group values are indicated by mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, compared with the IS group. 50%FMWT, 50% facial mechanical withdrawal threshold; 50%PMWT, 50% paw mechanical withdrawal threshold; TFL, tail-flick latency; HPL, hot-plate latency; CPB, cold-plate behaviors; EA, electroacupuncture; IS, inflammatory soup; aCSF, artificial cerebrospinal fluid; GB20, Fengchi; GB34, Yanglingquan; SJ17, Yifeng; ST36, Zusanli.