TABLE 2.

Exogenous proteins for manipulation of astroglia intracellular Ca²⁺.

Exogenous manipulations are described using the same principles as in Table 1: biological function; proven or expected dependence on IP₃R2; whether experiments were conducted in vivo and if so, whether done in awake (green) or anesthetized (orange) mice; and whether the Ca²⁺ signal is behavior-induced and if so, whether this was validated in awake (green) or anesthetized (orange) mice. * “Behavior-induced” indicates that a Ca²⁺ signal is caused by any form of sensory stimulation or awake behavior. Accepted manipulations are forms of acute or chronic suppression of endogenous signaling pathways. Any form of electrical, optical, or chemical overactivation of a nerve fiber tract or an endogenous or exogenous signaling pathway does not qualify.