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. 2021 Jun 12;14(9):101148. doi: 10.1016/j.tranon.2021.101148

Fig. 4.

Fig 4

CDK5 gene silencing improves the peripheral immune response. A, B and C. Flow cytometry analysis was performed to detect CD3+ T, CD4+ T and CD8+ T cells from spleens of control group and CDK5 knockdown group. **p < 0.01, ***p < 0.005. D and E. CD4+ T and CD8+ T cells from spleens of shCDK5 group and shCDK5+anti-PD-L1 group were detected by flow cytometry analysis. shC: shCDK5, shC+aPD-L1:shCDK5+anti-PD-L1, *p < 0.05, ***p < 0.005. F, G and H. Flow cytometry analysis was used to detect CD3+ PD-1+ T, CD4+ PD-1+ T and CD8+ PD-1+ T cells from spleens of control group and CDK5 knockdown group. All the antibody concentration used in flow cytometry is 1:100. *p < 0.05, **p < 0.01, NS: not significant.