Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 7;12:652923. doi: 10.3389/fimmu.2021.652923

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Indo, Kitahara, Tomokiyo, Araki, Islam, Zhou, Albarracin, Miyazaki, Ikeda-Ohtsubo, Nochi, Takenouchi, Uenishi, Aso, Takahashi, Kurata, Villena and Kitazawa

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Immunomodulatory effect of porcine Ligilactobacillus salivarius FFIG58 on porcine intestinal epithelial (PIE) cells in response to rotavirus infection, enterotoxigenic Escherichia coli (ETEC) challenge and ETEC and rotavirus infection. The differential modulation of interferons (IFNs) and antiviral factors, inflammatory cytokines and chemokines and negative regulators of the Toll-like receptor (TLR) signaling pathway induced by L. salivarius FFIG58 are highlighted. The heat-map analysis compares the immunomodulatory effects of FFIG35 and FFIG58 strains. The heat-maps were constructed considering the fold expression changes in RT-qPCR data, related to non-lactobacilli treated controls. (+) moderate up-regulation, (++) heightened up-regulation, (-) moderate down-regulation, (–) heightened down-regulation. The changes indicated by (-) and (+) were calculated by considering the percentages.