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. 2021 Jun 7;9:680491. doi: 10.3389/fcell.2021.680491

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Copyright © 2021 Zhai, Wu, Wang, Fan, Xie, Wu, He, Qian, Tan, Yao, He and Shen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CDDP, DXT, and Dox dosing in zebrafish. (A) zCDXs engrafted SGC7901 cells (dyed with red fluorescence using DiL) were treated with CDDP, DXT, or Dox at their 1/4, 1/2, and 1 MTD, and they inhibited cell proliferation in a dose-dependent manner (control-1, embryo medium for CDDP assay; control-2, embryo medium containing 0.1% DMSO for DXT or Dox assay) (*P < 0.05, **P < 0.01 vs. control-1 or control-2). (B) A protocol for preclinical chemosensitivity test in the zebrafish larvae cancer model was developed.