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The role of autophagy in developmental and mature B cells. Autophagy performs homeostatic roles in various B cell subsets. It is dispensable for the development of both B1 and B2 cells but is required for the peripheral self–renewal of B1 cells. Regarding B2 cells, autophagy is necessary for TLR–mediated, but not antigen–driven, activation. Autophagy also plays important roles in sustaining plasma cell immunoglobulin production and ensuring memory B cell survival.
