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. 2021 Jun 7;9:695657. doi: 10.3389/fcell.2021.695657

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Copyright © 2021 Hou, Du, Zhou, Hu, Wang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of PKC decreases the transmigration of macrophages from wAMD patients. An RCEC monolayer was pretreated with 1 μM of GF109203X for 2 hr. Macrophages from wAMD patients were then added and allowed to migrate for 4 h. Transmigrated macrophages were stained with a 0.5% gentian violet for 5 min and counted in five random fields. After GF109203X treatment, macrophage transmigration decreased in both JAM-C overexpressing and control RCECs. Compared with the control group without GF109203X treatment, JAM-C overexpressing RCECs treated with GF109203X did not induce any increase in macrophage transmigration. **P < 0.01, NS, not significant.