FIG. 2.

IOP and blood pressure in hound dogs after treatment with CKLP1. (A) Once-daily treatment of 10 mM CKLP1 caused sustained IOP reduction over a treatment period of 61 consecutive days in hound dogs with excellent tolerability and no observable ocular side effects. Each data point represents average absolute IOP values in mmHg (y axis) ± standard deviation for CKLP1 and vehicle- (PBS) treated eyes for a given day, plotted against time (x-axis). (B) CKLP1 treatment did not cause any changes in average systolic or diastolic blood pressures compared with baseline values.