Table 2.
Blood Chemistry of Hound Dogs After Ocular Topical Instillation of 50 mM Cromakalim Prodrug 1
| Average (Control) | Average (Treated) | Normal range (dogs) | |
|---|---|---|---|
| Sodium (Na+) (mM) | 144.5 ± 2.1 | 137.7 ± 8.5 | 139.0–154.0 |
| Potassium (K+) mM. | 5.0 ± 0.1 | 4.4 ± 0.5 | 3.6–5.5 |
| Total carbon dioxide (tCO2) mM | 25.0 ± 1.4 | 25.67 ± 2.1 | 14.0–26.0 |
| Chloride (CL−) (mM) | 108.5 ± 5.0 | 103.7 ± 4.9 | 102.0–120.0 |
| Glucose (mg/dL) | 86.5 ± 16.3 | 73.7 ± 10.6 | 70.0–138.0 |
| Calcium (Ca) mg/dL | 10.8 ± 0.3 | 10.6 ± 0.8 | 8.9–11.4 |
| Blood urea nitrogen (mg/dL) | 15.0 ± 1.4 | 9.3 ± 1.5 | 6.0–25.0 |
| Creatinine (mg/dL) | 0.8 ± 0.0 | 0.7 ± 0.1 | 0.5–1.6 |
| Alkaline Phosphatase (U/L) | 25.5 ± 3.5 | 22.7 ± 7.6 | 5.0–131.0 |
| Alanine aminotransferase (U/L) | 44.0 ± 1.4 | 41.7 ± 11.9 | 12.0–118.0 |
| Aspartate aminotransferase (U/L) | 26.0 ± 2.8 | 30.0 ± 4.4 | 15.0–66.0 |
| Total bilirubin (mg/dL) | 0.3 ± 0.0 | 0.3 ± 0.1 | 0.1–0.3 |
| Albumin (g/dL) | 1.4 ± 0.1 | 1.3 ± 0.1 | 2.7–4.4 |
| Total protein (g/dL) | 6.6 ± 0.6 | 6.6 ± 0.8 | 5.2–8.8 |