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. 2021 Jun 4;31(3):237–244. doi: 10.1089/nat.2020.0852

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© Christian Berk et al. 2021; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FIG. 2. — Nuclease stability in different biological matrices. Stability of siRNAs I–V in (A) 50% murine serum and (B) rat liver tritosome extracts. siRNAs were incubated either in 50% murine serum or standardized rat liver tritosome extracts (pH = 5), and aliquots were analyzed by ion-exchange high performance liquid chromatography at the indicated time points (n = 3).