Table 1.
Sequences of Small Interfering RNAs
| siRNA | Strand | Sequence (5′-3′) | M calc | M found | Target |
|---|---|---|---|---|---|
| siRNA I | AS | AAAUCCUUCCAUGAAUAGUTT | 6599.07 | 6598.83 | Lin28B |
| S | ACUAUUCAUGGAAGGAUUUTT | 6656.09 | 6655.29 | ||
| siRNA II | AS | AAAUCCUUCCAUGAAUAGUTT | 6920.38 | 6919.45 | Lin28B |
| S | ACUAUUCAUGGAAGGAUUUTT | 6977.40 | 6976.11 | ||
| siRNA III | AS | aAaucCuuccaugAaUaguuu | 6913.65 | 6912.87 | Lin28B |
| S | acuauuCaUGGaaggauuuuu | 6970.65 | 6969.91 | ||
| siRNA IV | AS | AUGGAAuACUCUUGGUuACTT | 6660.07 | 6659.25 | TTR |
| S | GuAAccAAGAGuAuuccAuTT | 6764.32 | 6763.61 | ||
| siRNA V | AS | uUgAaGuAaAuggUgUuAaCcag | 7675.03 | 7674.09 | Serpinc 1 |
| S | GgUuAaCaCCAuUuAcUuCaA | 6784.26 | 6783.30 |
Upper case is RNA, upper case underlined is 2′-F, lower case is 2′-OMe, PS linkages are in bold. Sequences of siRNA IV and V retrieved from patents US20170307608A1 and US20170159053A1, respectively.
siRNA, small interfering RNA; PS, phosphorothioate.