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. 2021 Jun 7;12:668640. doi: 10.3389/fneur.2021.668640

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Copyright © 2021 den Hollander, Rasing, Post, Klein, Oud, Brands, de Boer, Engelke, van Essen, Fuchs, Haaxma, Jensson, Kluijtmans, Lengyel, Lichtenbelt, Østergaard, Peters, Salvarinova, Simon, Stefansson, Thorarensen, Ulmen, Coene, Willemsen, Lefeber and Karnebeek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Prenatal 3D ultrasound of patient 2 at 34 weeks 2 days' gestational age, frontal view showing carpe-shaped mouth with tenting of both upper and lower lip. (B) Prenatal 3D ultrasound of patient 2 at 34 weeks 2 days' gestational age, lateral view showing craniofacial features with depressed nasal bridge, upturned nasal tip and prominent upper lip. (C) Facial features of patient 4 at age 10 months, frontal view showing depressed midface with full cheeks and prominent philtral ridges. (D) Facial features of patient 4 at age 10 months, lateral view showing deep-set eyes and low-set ears. (E) Facial features of patient 1 at age 3 years, frontal view showing high forehead, depressed midface, full cheeks, and tented mouth. (F) Facial features of patient 1 at age 3 years, lateral view showing deep-set eyes, upturned nasal tip, and low-set and posteriorly rotated ears. (G) Facial features of patient 5 at age 7 years, frontal view showing minimal dysmorphic features with tented upper lip and widely spaced teeth. (H) Facial features of patient 5 at age 7 years, lateral view showing mild posterior rotated and low-set ear and prominent, short, philtrum.