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. 2021 Jun 7;9:681186. doi: 10.3389/fcell.2021.681186

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Copyright © 2021 Jiang, Li, Li, Liu, Hoffman and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Neddylation regulates the polarization of macrophages. (A,B,D) Flow cytometric analysis of MLN4924-treated BMDMs, LPS and IFN-γ-induced Ml macrophages, and IL-4-induced M2 macrophages. BMDMs were isolated from 8-week old wild type mouse and stimulated with L929 supernatant for 7 days, and then treated with MLN4924 (0.5 μM for 24 h). (C) The expression of iNOS in BMDMs after stimulation by LPS and IFN-γ for 24 h.