Table 4.
Estimates of lung cancer risk for groups defined jointly by smoking status and quintiles of PRS, UK Biobank, 2006–2016
| Q1 (lowest) | Q2 | Q3 | Q4 | Q5 (highest) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Smoking status | No. cases | HRa | No. cases | HRa | No. cases | HRa | No. cases | HRa | No. cases | HRa |
| Never smokers | 27 | 1 (reference) | 30 | 1.11 (0.66–1.87) | 33 | 1.23 (0.74–2.05) | 37 | 1.36 (0.83–2.24) | 52 | 1.90 (1.20–3.03) |
| Current heavy smokersb | 51 | 25.4 (15.9–40.6) | 75 | 36.1 (23.2–56.1) | 73 | 32.7 (21.0–51.0) | 84 | 36.9 (23.9–57.1) | 82 | 36.1 (23.3–55.9) |
| Former heavy smokersc | 45 | 15.1 (9.37–24.4) | 49 | 15.5 (9.67–24.8) | 55 | 17.6 (11.1–27.9) | 63 | 19.1 (12.2–30.1) | 77 | 22.4 (14.4–34.8) |
| Current less-heavy smokersd | 17 | 19.4 (10.5–35.6) | 17 | 19.8 (10.8–36.4) | 15 | 18.0 (9.57–33.9) | 21 | 27.0 (15.2–47.8) | 36 | 45.5 (27.6–75.0) |
| Other current smokers | 16 | 6.92 (3.73–12.9) | 21 | 9.51 (5.37–16.8) | 30 | 14.3 (8.48–24.0) | 33 | 15.8 (9.50–26.3) | 31 | 16.1 (9.62–27.0) |
| Other former smokers | 56 | 2.88 (1.82–4.55) | 67 | 3.47 (2.22–5.43) | 87 | 4.51 (2.93–6.95) | 82 | 4.33 (2.80–6.69) | 87 | 4.63 (3.00–7.13) |
aHRs were adjusted for sex, education, first 10 principal components and genotype array.
bCurrent heavy smokers: current smokers with a smoking history of ≥30 pack-years.
cFormer heavy smokers: former smokers with a smoking history of ≥30 pack-years and quit within 15 years.
dCurrent less-heavy smokers: current smokers with a smoking history of 20–29 pack-years.