Table 2:

Clinicopathologic characteristics associated with disease-free survival, with LKB1/STK11 expression analyzed as a continuous variable (n = 104).

		Univariate			Multivariate
		HR	95% CI	P	HR	95% CI	P
Age (≥65 years)	49 (47.1)	1.48	0.91–2.41	0.118	1.56	0.93–2.62	0.09
Sex (Male)	53 (51.0)	1.86	1.13–3.06	0.015
Smoker (Ever)	89 (85.6)	0.86	0.44–1.69	0.658
Zubrod (1)	47 (45.2)	1.29	0.79–2.10	0.304
FEV1 (% Predicted)*	n/a	1.00	0.99–1.02	0.879
Pathologic Stage
I	62 (59.6)	Reference			Reference
II	24 (23.1)	2.49	1.40–4.44	0.002	2.37	1.31–4.27	0.004
III	18 (17.3)	3.43	1.86–6.33	<0.001	2.83	1.40–5.73	0.004
Differentiation (Poor)	43 (41.4)	1.11	0.68–1.83	0.668
Extent of resection (Pneumonectomy)	4 (3.8)	1.41	0.44–4.49	0.564
Margin (R1)	4 (3.8)	4.47	1.57–12.69	0.005	2.33	0.71–7.63	0.161
LKB1/STK11 expression (H-score, per 10 unit increase)	n/a	0.96	0.93–1.00	0.029	0.96	0.93–1.00	0.044
Adjuvant Chemotherapy	23 (22.1)	1.06	0.60–1.90	0.838	0.74	0.39–1.42	0.367
Adjuvant Radiotherapy	13 (12.5)	2.78	1.48–5.24	0.002	2.12	1.02–4.39	0.044

^*Data available for 103/104 (99.0%)

CI: confidence interval; FEV1: forced expiratory volume in one second; HR: hazard ratio