Table 3:

Clinicopathologic characteristics associated with distant disease-free survival, with LKB1/STK11 expression analyzed as a continuous variable (n = 104).

		Univariate			Multivariate
		HR	95% CI	P	HR	95% CI	P
Age (≥65 years)	49 (47.1)	1.55	0.95–2.54	0.082	1.62	0.96–2.73	0.069
Sex (Male)	53 (51.0)	1.96	1.18–3.25	0.009
Smoker (Ever)	89 (85.6)	0.94	0.48–1.85	0.858
Zubrod (1)	47 (45.2)	1.18	0.72–1.94	0.501
FEV1 (% Predicted)*	n/a	1.00	0.98–1.02	0.871
Pathologic Stage
I	62 (59.6)	Reference			Reference
II	24 (23.1)	2.44	1.37–4.35	0.003	2.38	1.32–4.30	0.004
III	18 (17.3)	3.59	1.92–6.73	<0.001	3.41	1.69–6.85	0.001
Differentiation (Poor)	43 (41.4)	1.12	0.68–1.84	0.665
Extent of resection (Pneumonectomy)	4 (3.8)	1.51	0.47–4.82	0.488
Margin (R1)	4 (3.8)	4.33	1.31–14.32	0.016	2.11	0.56–7.90	0.266
LKB1/STK11 expression (H-score, per 10 unit increase)	n/a	0.96	0.92–0.99	0.014	0.95	0.92–0.99	0.013
Adjuvant Chemotherapy	23 (22.1)	0.86	0.47–1.56	0.617	0.59	0.31–1.14	0.118
Adjuvant Radiotherapy	13 (12.5)	2.30	1.20–4.41	0.012	1.97	0.93–4.14	0.075

^*Data available for 103/104 (99.0%)

CI: confidence interval; FEV1: forced expiratory volume in one second; HR: hazard ratio