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. 2021 Jun 7;12:637598. doi: 10.3389/fimmu.2021.637598

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Copyright © 2021 Zhou, Li, Chen, Huang, Qin and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of miR-186-5p suppressed cardiomyocyte pyroptosis through regulation of XIAP. (A) A CCK-8 assay used to gauge H9C2 cardiomyocyte viability (n = 3). Supernatant (B) LDH, (C) IL-1β, and (D) IL-18 levels were measured via ELISA (n = 6). (E-J) Western blotting was used to quantify cardiomyocyte XIAP, NLRP3, ASC, caspase-1 p20, and GSDMD protein levels with GAPDH as a loading control (n = 3). Data are mean ± SEM from three or more independent experiments. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.