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. 2021 Jun 7;15:670430. doi: 10.3389/fnins.2021.670430

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Copyright © 2021 Beecher, Alvarez Cooper, Wang, Walters, Chehrehasa, Bartlett and Belmer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Long-term sucrose consumption produces hyperactivity and reduces the control to resist food. Tracking plot of water- (A) and sucrose-consuming mice (B) illustrating that long-term sucrose consumption increases the total distances traveled in the open field (C), the speed in the center (D) and total speed (E) in the open-field compared to water controls. Long-term sucrose consumption also reduced the latency to feed suggesting reduced control to resist food (F). Data are presented as mean ± SEM; n = 8 mice/group. ***p < 0.001, ****p < 0.0001.