Table 6.
Characteristics relevant to regulatory applicability of the in vitro models presented in the webinar series. PCLS, precision-cut lung slices.
| MucilAir (Epithelix) | EpiAirway (MatTek) | Micro-Lung | Metabo-Lung | Lung-on-a-chip | PCLS | |
|---|---|---|---|---|---|---|
| Uses normal human cells | x | x | x | x | x | x |
| Can be maintained at the ALI | x | x | x | x | x | x |
| Mimics aspects of human lung morphology and physiology | x | x | x | x | x | x |
| Cilia beating | x | x | x | x | x | x |
| Production of mucous | x | x | x | x | x | x |
| Potential for metabolic activity | x | x | – | x | x | x |
| Suitable for long-term culture | x | x | x | x | x | x |
| Incorporates cyclic breathing and hemodynamic flow | – | – | – | – | x | – |
| Includes immune cells | x | x | – | – | x | x |
| Commercially available | x | x | – | – | – | – |