Table 1.
Summary of expression of CX3CR1 and chemotactic, adhesive and other physiological responses to CX3CL1 in major immune cell subtypes.
| Cell Type | CX3CR1 Expression | Chemotactic Response to CX3CL1 | Adhesion Response to CX3CL1 | Other Responses to CX3CL1 |
|---|---|---|---|---|
| Monocytes | Yes (higher on non-classical monocytes) | Yes (variable data regarding subset-specific response) | Yes | Crawling on vasculature (nonclassical subset) Survival via anti-apoptotic signalling in both steady state and atherosclerosis |
| Macrophages | Yes | Yes | Not reported | Maturation and survival |
| Dendritic Cells | High expression by cDC, low or absent expression on pDC | Yes (cDC) | Not reported | Maturation and survival |
| T-cells | Some subtypes | Some subtypes | Some subtypes | Cell survival in inflammatory lung disease |
| B-cells | No | No | No | N/A |
| NK-cells | Yes | Yes | Yes (after activation) | None reported |
| Neutrophils | No (mRNA expression reported) | Varying Reports* | No | Possible cell survival role in steady-state |
cDC, conventional dendritic cells; pDC, plasmacytoid dendritic cells; *Pan et al. reported an effect on neutrophil chemotaxis but this was not shown in subsequent studies, Becker et al. suggested a possible role in in vivo recruitment (28).