Figure 4.

. Development of experimental arthritis induced by CFA in CD-1 mice. (A) - evaluation of the paw edema severity in CFA-induced arthritis in mice of control, CFA-control (treatment of NS), 17.1A, Norocarp, 17.1 (CFA—complete Freund’s adjuvant; NS—normal saline). All data are presented as mean ± SEM for at least three independent replicates. ^ap < 0.05, ^bp < 0.01 vs CFA+NS; *p < 0.05, ^**p < 0.01 vs baseline on 1 day. (B) – Intact paw (score 0); (C) – paw on 3 days after CFA-induced arthritis with peptide 17.1A (score 2); (D) – paw on 3 days after CFA-induced arthritis with NS (score 3). (n = 10 in each group).