Table 2.
Frequency distribution of MBL2 and TOLLIP gene polymorphisms in HIV infected patients and healthy controls
| Gene | SNPs | Allele/ Genotype | Case group N(%) | Control group N(%) | OR(95%CI) | P | ORa(95% CI) | Pa |
|---|---|---|---|---|---|---|---|---|
| MBL2 gene | rs7096206(C > G) | Allele | ||||||
| C | 714 (0.820) | 1678 (0.831) | 1 | Reference | 1 | Reference | ||
| G | 156 (0.179) | 340 (0.168) | 0.998 (0.820–1.214) | 0.983 | 1.050 (0.853–1.294) | 0.644 | ||
| Genotype | ||||||||
| CC | 293 (0.673) | 706 (0.699) | 1 | Reference | 1 | Reference | ||
| GC | 128 (0.294) | 266 (0.263) | 1.159 (0.902–1.490) | 0.248 | 1.170 (0.899–1.521) | 0.243 | ||
| GG | 14 (0.032) | 37 (0.036) | 0.955 (0.697–1.308) | 0.774 | 1.023 (0.734–1.426) | 0.892 | ||
| rs1800450(C > T) | Allele | |||||||
| C | 735 (0.846) | 1667 (0.826) | 1 | Reference | 1 | Reference | ||
| T | 133 (0.153) | 351 (0.173) | 0.855 (0.699–1.045) | 0.127 | 0.886 (0.716–1.096) | 0.266 | ||
| Genotype | ||||||||
| CC | 312 (0.718) | 689 (0.682) | 1 | Reference | 1 | Reference | ||
| TC | 111 (0.255) | 289 (0.286) | 0.848 (0.656–1.096) | 0.208 | 0.860 (0.658–1.125) | 0.271 | ||
| TT | 11 (0.025) | 31 (0.030) | 0.885 (0.624–1.257) | 0.495 | 0.901 (0.624–1.301) | 0.578 | ||
| TOLLIP gene | rs5743899(T > C) | Allele | ||||||
| T | 504 (0.581) | 1268 (0.628) | 1 | Reference | 1 | Reference | ||
| C | 362 (0.418) | 750 (0.371) | 1.196 (1.026–1.393) | 0.022 | 1.231 (1.048–1.446) | 0.011 | ||
| Genotype | ||||||||
| TT | 149 (0.344) | 409 (0.405) | 1 | Reference | 1 | Reference | ||
| CT | 206 (0.475) | 450 (0.445) | 1.257 (0.979–1.613) | 0.073 | 1.274 (0.980–1.655) | 0.070 | ||
| CC | 78 (0.180) | 150 (0.148) | 1.195 (1.012–1.410) | 0.036 | 1.198 (1.008–1.424) | 0.040 | ||
| rs3750920(C > T) | Allele | |||||||
| C | 607 (0.700) | 1391 (0.689) | 1 | Reference | 1 | Reference | ||
| T | 259 (0.299) | 627 (0.310) | 0.960 (0.816–1.129) | 0.622 | 0.949 (0.799–1.126) | 0.547 | ||
| Genotype | ||||||||
| CC | 207 (0.478) | 486 (0.481) | 1 | Reference | 1 | Reference | ||
| TC | 193 (0.445) | 419 (0.415) | 1.081 (0.854–1.369) | 0.515 | 0.999 (0.780–1.279) | 0.994 | ||
| TT | 33 (0.076) | 104 (0.103) | 0.863 (0.698–1.067) | 0.174 | 0.861 (0.690–1.075) | 0.186 | ||
| rs5743867(A > G) | Allele | |||||||
| A | 503 (0.590) | 1290 (0.639) | 1 | Reference | 1 | Reference | ||
| G | 349 (0.409) | 728 (0.360) | 1.356 (1.175–1.564) | < 0.001 | 1.387 (1.191–1.615) | < 0.001 | ||
| Genotype | ||||||||
| AA | 152 (0.356) | 424 (0.420) | 1 | Reference | 1 | Reference | ||
| GA | 199 (0.467) | 442 (0.438) | 1.256 (0.978–1.612) | 0.074 | 1.285 (0.0.989–1.669) | 0.060 | ||
| GG | 75 (0.176) | 143 (0.141) | 1.210 (1.023–1.430) | 0.026 | 1.222 (1.026–1.455) | 0.012 |
Abbreviation: MBL2 mannose binding lectin 2; TOLLIP toll-interacting protein; SNPs single nucleotide polymorphisms; OR odds ratio; CI confidence interval; a, adjusted for age and gender