Table 3.
Association between genetic models of gene polymorphisms and susceptibility to HIV infection
| SNPs | Genetic model | OR(95%CI) | P | ORa(95% CI) | Pa | |
|---|---|---|---|---|---|---|
| rs7096206(C > G) | Dominant model | GG + GC vs. CC | 1.068 (0.848–1.346) | 0.576 | 1.108 (0.867–1.415) | 0.414 |
| Recessive model | GG vs. CC + GC | 0.729 (0.426–1.245) | 0.247 | 0.846 (0.480–1.490) | 0.562 | |
| Additive model | 2GG + GC vs.CC | 1.036 (0.849–1.264) | 0.729 | 1.078 (0.873–1.331) | 0.485 | |
| rs1800450(C > T) | Dominant model | TT + TC vs. CC | 0.840 (0.663–1.064) | 0.148 | 0.867 (0.676–1.112) | 0.262 |
| Recessive model | TT vs. CC + TC | 0.826 (0.497–1.374) | 0.462 | 0.897 (0.524–1.534) | 0.691 | |
| Additive model | 2TT + TC vs. CC | 0.857 (0.695–1.057) | 0.149 | 0.882 (0.708–1.099) | 0.262 | |
| rs5743899(T > C) | Dominant model | CC + CT vs. TT | 1.273 (1.020–1.590) | 0.033 | 1.317 (1.042–1.664) | 0.021 |
| Recessive model | CC vs. TT + CT | 1.213 (0.929–1.584) | 0.157 | 1.263 (0.95–1.673) | 0.104 | |
| Additive model | 2CC + CT vs. TT | 1.200 (1.026–1.402) | 0.022 | 1.218 (1.034–1.435) | 0.018 | |
| rs3750920(C > T) | Dominant model | TT + TC vs. CC | 1.019 (0.822–1.263) | 0.862 | 0.971 (0.774–1.218) | 0.799 |
| Recessive model | TT vs. CC + TC | 0.802 (0.566–1.135) | 0.213 | 0.856 (0.595–1.231) | 0.402 | |
| Additive model | 2TT + TC vs. CC | 0.953 (0.805–1.128) | 0.574 | 0.932 (0.780–1.115) | 0.442 | |
| rs5743867(A > G) | Dominant model | GG + GA vs. AA | 1.424 (1.155–1.757) | 0.001 | 1.469 (1.176–1.834) | 0.001 |
| Recessive model | GG vs. AA+GA | 1.461 (1.151–1.855) | 0.002 | 1.500 (1.163–1.934) | 0.002 | |
| Additive model | 2GG + GA vs. AA | 1.282 (1.101–1.494) | 0.001 | 1.305 (1.111–1.532) | 0.001 |
Abbreviation: SNPs single nucleotide polymorphisms; OR odds ratio; CI confidence interval; a adjusted for age and gender