Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jun 21;40:200. doi: 10.1186/s13046-021-01994-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 1 — IMP3 is upregulated in human CRC patients and predicted poor prognosis. (A) Heatmap of differentially expressed mRNAs related to RNA binding proteins between adjacent normal mucosa (N), cancer tissue (T), and liver metastases tissue (M) from 8 paired colon cancer tissues. (B) IMP3 mRNA expression level in adjacent normal mucosa (N), cancer tissue (T), and liver metastases tissue (M) from 8 paired colon cancer tissues. (C) Expression of IMP3 in the TCGA CRC RNAseq dataset (Normal n = 51, Tumor n = 647). (D) Expression of IMP3 in the FUSCC dataset (Normal n = 61, Tumor n = 72). (E) IMP3 expression in 59 paired CRC tissues and its adjacent normal mucosa. (F-H) The expression of IMP3 in CRC tissue microarrays by IHC. (F) IMP3 was overexpressed in CRC tissues (p < 0.05). (G) IMP3 overexpression was associated with AJCC stage (p < 0.05). (H) MP3 overexpression was associated with tumor distal metastasis (p < 0.05). (I) Representative images of IMP3 expression in CRC tissues by Western blot analysis. (J) High IMP3 expression predicted shorter DFS than that of patients with low IMP3 expression. (K) High IMP3 expression predicted shorter OS than that of patients with low IMP3 expression