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. 2021 Jun 21;40:200. doi: 10.1186/s13046-021-01994-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — IMP3 promotes CRC cell proliferation and metastasis in vivo. (A-B) 2 × 10⁶ stable cells were injected subcutaneously into the groin of nude mice (n = 5 for either group). (A) Knockdown of IMP3 declined tumor growth and tumor weights compared with those control cells in HCT116 (B) Overexpression of IMP3 promoted tumor growth and tumor weights compared with those control cells in LOVO. (C) Representative images of IHC staining for IMP3, MEKK1, MEK1 and p-ERK. (D) Representative images of lung metastasis in nude mice with HE staining. (left) Knockdown of IMP3 reduced the number of lung metastasis nodular compared with those control cells in HCT116, (right) Overexpression of IMP3increased the number of lung metastasis nodular compared with those control cells in LOVO (* p < 0.05). (E) Representative image of nude mice bearing tumors formed by overexpression of IMP3 in LOVO and their control cells after U0126 treatment. The average tumor volume and tumor weight of nude mice bearing tumors formed by overexpression of IMP3 in LOVO and their control cells after U0126 treatment. (* p < 0.05, ** p < 0.05) (F) Representative image of nude mice bearing tumors formed by stable knockdown of IMP3 in HCT116 and their control cells after U0126 treatment. The average tumor volume and tumor weight of nude mice bearing tumors formed by stable knockdown of IMP3 in HCT116 and their control cells after U0126 treatment. (* p < 0.05, ** p < 0.05)