Fig. 1.

Graphical representation of the 26 families used as discovery cohort. Pedigrees of the 26 Italian families with supposedly dominant PD forms. Affected individuals are indicated with dark symbols. Patients who underwent WES analysis are shown with dark arrows. Additional family members for which DNA was available are indicated with an asterisk. Only affected subjects were used for segregation analysis. For each family, the rare deleterious variants reported in Table 1 were carried by the affected family members